Higher EA HOMA-IR was associated with worse attention. Among AA, higher C/A FPG was associated with worse attention, EF, and GC. Higher C/A HOMA-IR and FPI were associated with better memory, as was higher EA FPI. Among men, higher EA HOMA-IR was associated with worse attention. Higher EA FPG was associated with poorer WM. Among women, higher C/A FPG was associated with poorer memory and poorer GC. Results: Sample was 59% women, 34% African American (AA). Linear regression models were analyzed for each epoch and separate models were analyzed with sex and race, education as a covariate. Glycemic markers (i.e., FPG, FPI, and HOMA-IR) averaged within lifespan epochs (≤ 20 years, childhood/adolescence (C/A) 21–40 years, early adulthood (EA) and 40–58 years, midlife). Memory, executive function (EF), attention, working memory (WM), and global cognition (GC), collected 2013–2016. 1,295 participants in the Bogalusa Heart Study, a biracial epidemiological cohort located in a micropolitan area core setting, provided fasting plasma insulin (FPI) and glucose (FPG) biannually from 1973 to 2016. Methods: This study used cross-sectional analysis of prospectively maintained cohort. Introduction: Glycemic markers throughout life are associated with increased risk of midlife cognitive decline, yet it is unclear whether these associations differ by race and sex. 3Biomedical Imaging Center, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States.2Tulane Center for Lifespan Epidemiology Research, Tulane University School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, United States.1Physical Activity and Ethnic Minority Health Laboratory, Department of Population and Public Health Sciences, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States.
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